Fig. 2

Correlation between virion morphology and protein components. a Thin-section TEM image showing immature and mature VACV virions inside host cytoplasm in which specific protein (A14) is identified by immuno-gold labeling. b Aberrant virion assembly induced by the addition of assembly inhibitor, rifampicin, showing electron-dense aggregation instead of properly assembled virions. c Aberrant virion assembly in the absence of viral protein A30 in which the protein expression was controlled by IPTG induction. Scale bars are 0.5 μm. The images are reprinted with permission, from a, b Wolffe et al. Journal of Virology, 1996, doi: https://doi.org/10.1128/JVI.70.5.2797-2808.1996, c Szajner et al. Journal of Virology, 2001, doi: https://doi.org/10.1128/JVI.75.13.5752-5761.2001.