Ultrastructural changes in cristae of lymphoblasts in acute lymphoblastic leukemia parallel alterations in biogenesis markers

Applied Microscopy

Table 3 Spearman correlation between biogenesis markers and cristae parameter in 15 ALL patients

	Average M/C ratio		Cristae cross sectional area
	r value	p value	r value	p value
POLG gene expression	0.0	> 0.99	−0.32	0.25
PGC-1α gene expression	0.36	0.18	0.36	0.19
TFAM gene expression	−0.05	0.86	− 0.34	0.24
c-myc gene expression	−0.36	0.18	−0.41	0.15
CS gene expression	−0.28	0.32	−0.42	0.13

The bold typeface indicates p-values approaching significance
POLG Polymerase γ, TFAM Mitochondrial transcription factor A, CS Citrate synthase, r Spearman correlation coefficient
p < 0.05, ** p < 0.01, *** p < 0.001