Skip to main content
Fig. 3 | Applied Microscopy

Fig. 3

From: Ultrastructural changes in cristae of lymphoblasts in acute lymphoblastic leukemia parallel alterations in biogenesis markers

Fig. 3

A Scatter plot representation of average M/C ratio in ALL patients (n = 15) and controls (n = 9); p = 0.046. Transmission electron images were analyzed for qualitative differences between ALL patients and healthy controls; arrow depicting mitochondria in the TEM images. B Thicker and denser cristae in mitochondria in lymphoblast of a T-ALL patient (left; 9900X; scale bar = 0.2 μm) as compared to lymphocyte of BM control (right; 9900X; scale bar = 0.2 μm). C Thicker and denser cristae in mitochondria in lymphoblast of a B-ALL patient (left; 5000X; scale bar = 0.5 μm) as compared to lymphocyte of patient’s sibling (right; 5000X; scale bar = 0.5 μm). D Bar graph representation of cristae cross-sectional area in mitochondria (n = 165) of lymphoblasts of 15 ALL patients versus mitochondria (n = 84) in lymphocytes of 9 healthy control along with medians depicted on top of the bars in each group; p < 0.0001. These numbers 165 and 84 suggests multiple mitochondria in each section were analysed in ALL patients and controls (* p < 0.05, ** p < 0.01, *** p < 0.001, Mann-Whitney U test). OMM- Outer Mitochondrial Membrane

Back to article page