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Applied Microscopy
Fig. 1 | Applied Microscopy

Fig. 1

From: Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse

Fig. 1

a, b DiI-labeled hTMSCs (red) were observed in the subretinal space (SRS) of the retina. In A, rhodopsin (white) was expressed in the outer segment of the rod photoreceptor in outer and inner segments layer (OS/IS) and near two injected hTMSCs. In b, Opsin (green) was expressed in the cone photoreceptors. However, hTMSCs (red) did not express opsin. DAPI was counterstained for nuclei of the retina. RPE, retinal pigment epithelium; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer. c, d. C and D were magnified from A and B, respectively. A few rhodopsin-labeled puncta (white in C) are placed close to the hTMSCs (red in C), while opsin-labeled puncta (green in D) are absent around the hTMSCs (red in D). e In this higher magnified merged image of DIC and confocal image showing rhodopsin immunoreactivity, three rhodopsin-labeled puncta (arrows) appears to be bulging appendages of two DiI-labeled hTMSCs (red)

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